Of the classical vision-producers the best known are the peyote of Mexico and the southwestern United States and Cannabis sativa , consumed all over the world under such names as hashish, bhang, kif and marihuana. According to the best medical and anthro­pological evidence, peyote is far less harmful than the White Man's gin or whisky. It permits the Indians who use it in their religious rites to enter paradise, and to feel at one with the beloved community, without making them pay for the privilege by anything worse than the ordeal of having to chew on something with a revolting flavor and of feeling somewhat nauseated for an hour or two. Cannabis sativa is a less innocuous drug — though not nearly so harmful as the sen­sation-mongers would have us believe. The Medical Committee, appointed in 1944 by the Mayor of New York to investigate the problem of marihuana, came to the conclusion, after careful investigation, that Can­nabis sativa is not a serious menace to society, or even to those who indulge in it. It is merely a nuisance.

From these classical mind-changes we pass to the latest products of psychopharmacological research. Most highly publicized of these are the three new tranquillizers, reserpine, chlorpromazine and meprobamate. Administered to certain classes of psychotics, the first two have proved to be remarkably effective, not in curing mental illnesses, but at least in temporarily abolishing their more distressing symptoms. Meproba­mate (alias Miltown) produces similar effects in per­sons suffering from various forms of neurosis. None of these drugs is perfectly harmless; but their cost, in terms of physical health and mental efficiency, is ex­traordinarily low. In a world where nobody gets any­thing for nothing tranquillizers offer a great deal for very little. Miltown and chlorpromazine are not yet soma; but they come fairly near to being one of the aspects of that mythical drug. They provide temporary relief from nervous tension without, in the great ma­jority of cases, inflicting permanent organic harm, and without causing more than a rather slight im­pairment, while the drug is working, of intellectual and physical efficiency. Except as narcotics, they are probably to be preferred to the barbiturates, which blunt the mind's cutting edge and, in large doses, cause a number of undesirable psychophysical symp­toms and may result in a full-blown addiction.

In LSD-25 (lysergic acid diethylamide) the phar­macologists have recently created another aspect of soma — a perception-improver and vision-producer that is, physiologically speaking, almost costless. This ex­traordinary drug, which is effective in doses as small as fifty or even twenty-five millionths of a gram, has power (like peyote) to transport people into the other world. In the majority of cases, the other world to which LSD-25 gives access is heavenly; alternatively it may be purgatorial or even infernal. But, positive, or negative, the lysergic acid experience is felt by al­most everyone who undergoes it to be profoundly significant and enlightening. In any event, the fact that minds can be changed so radically at so little cost to the body is altogether astonishing.

Soma was not only a vision-producer and a tranquil­lizer; it was also (and no doubt impossibly) a stimu­lant of mind and body, a creator of active euphoria as well as of the negative happiness that follows the re­lease from anxiety and tension.

The ideal stimulant — powerful but innocuous — still awaits discovery. Amphetamine, as we have seen, was far from satisfactory; it exacted too high a price for what it gave. A more promising candidate for the role of soma in its third aspect is Iproniazid, which is now being used to lift depressed patients out of their misery, to enliven the apathetic and in general to in­crease the amount of available psychic energy. Still more promising, according to a distinguished phar­macologist of my acquaintance, is a new compound, still in the testing stage, to be known as Deaner. Deaner is an amino-alcohol and is thought to increase the production of acetyl-choline within the body, and thereby to increase the activity and effectiveness of the nervous system. The man who takes the new pill needs less sleep, feels more alert and cheerful, thinks faster and better — and all at next to no organic cost, at any rate in the short run. It sounds almost too good to be true.

We see then that, though soma does not yet exist (and will probably never exist), fairly good substi­tutes for the various aspects of soma have already been discovered. There are now physiologically cheap tranquillizers, physiologically cheap vision-producers and physiologically cheap stimulants.

That a dictator could, if he so desired, make use of these drugs for political purposes is obvious. He could ensure himself against political unrest by changing the chemistry of his subjects' brains and so making them content with their servile condition. He could use tranquillizers to calm the excited, stimulants to arouse enthusiasm in the indifferent, halluciants to distract the attention of the wretched from their miseries. But how, it may be asked, will the dictator get his subjects to take the pills that will make them think, feel and behave in the ways he finds desirable? In all probabil­ity it will be enough merely to make the pills available. Today alcohol and tobacco are available, and people spend considerably more on these very unsatisfactory euphorics, pseudo-stimulants and sedatives than they are ready to spend on the education of their children. Or consider the barbiturates and the tranquillizers. In the United States these drugs can be obtained only on a doctor's prescription. But the demand of the Ameri­can public for something that will make life in an urban-industrial environment a little more tolerable is so great that doctors are now writing prescriptions for the various tranquillizers at the rate of forty-eight millions a year. Moreover, a majority of these prescrip­tions are refilled. A hundred doses of happiness are not enough: send to the drugstore for another bottle — and, when that is finished, for another. . . . There can be no doubt that, if tranquillizers could be bought as easily and cheaply as aspirin, they would be con­sumed, not by the billions, as they are at present, but by the scores and hundreds of billions. And a good, cheap stimulant would be almost as popular.